dna test etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster
dna test etiketine sahip kayıtlar gösteriliyor. Tüm kayıtları göster

11 Mart 2008 Salı

From the NYT: DNA Tests Offer Immigrants Hope or Despair



Although the article in today’s New York Times - “DNA Tests Offer Immigrants Hope or Despair” by Rachel L. Swarns - uses traditional paternity or maternity tests and not genetic genealogy tests, the emotional results of the tested can often be the same. What if DNA proves that your father isn’t your biological father? What happens when there is uncontestable proof that there was an NPE (non-paternal event) in your great-grandfather’s ancestry?
According to the article, federal officials in the Immigration Department are using “genetic testing to verify the biological bonds between new citizens and the overseas relatives they hope to bring here, particularly those from war-torn or developing countries where identity documents can be scarce or doctored.”
For example, Isaac has been in the U.S. away from his native Ghana and his four boys for 14 years. When he became an American citizen and the Immigration Department suggested that he take a DNA test to prove the biological relationship to his four sons, he agreed. Unfortunately, only the oldest boy was his biological child. That child could come to the U.S., but Isaac would have to find another way to bring over the other three children.
How often does this happen? “Mary K. Mount, a DNA testing expert for the A.A.B.B. - formerly known as the American Association of Blood Banks - estimates that about 75,000 of the 390,000 DNA cases that involved families in 2004 were immigration cases. Of those, she estimates, 15 percent to 20 percent do not produce a match.” That’s over 10,000 cases in one year alone!
Interestingly, many lawyers working with immigrants believe that the government’s use of DNA testing burdens immigrants because of the high price of the testing - as much as $450 to test a parent and child. As well, federal officials “acknowledge that genetic testing can carry an emotional toll.”
This is true for any type of testing, be it a paternity test, an mtDNA test, or (someday) a full genomic sequencing. Everyone has a picture of their own past in their mind, a collection of beliefs and identities that they’ve learned or heard or perhaps have made up. Evidence of another past based on DNA can often shatter those beliefs.
As these families struggle to come to terms with the results of the testing, they often come to the conclusion that the biological definition of family is not the only definition available. My favorite line in the story comes from Balfour Francis, a 44-year-old Jamaican-born welder in Brooklyn who is trying to have his daughter join him in America. After the DNA test showed that he is not the girl’s father, he stated, “I will not let anybody dictate who is my child.” Although the results can be painful and have a severe emotional toll, they do not change the love a parent has for a child.
As for Isaac, his immigration lawyer determined “that he could petition for the teenagers as their stepfather. He must prove that the boys are the children of his deceased wife. Isaac hopes that a DNA test of one of his wife’s siblings, which could be compared with that of the teenagers, would provide that proof.”
I highly recommend reading this article if you are interested in DNA testing. I’m sure that this will spark another wave of insightful and interesting discussion on the blogosphere, similar to the very controversial article I discussed previously here.

10 DNA Testing Myths Busted

1. Genetic genealogy is only for hardcore genealogists.
Wrong! If you’ve ever wondered about the origins of your DNA, or about your direct paternal or maternal ancestral line, then genetic genealogy might be an interesting way to learn more. Although DNA testing of a single line, such as through an mtDNA test, will only examine one ancestor out of 1024 potential ancestors at 10 generations ago, this is a 100% improvement over 0 ancestors out of 1024. If you add your father’s Y-DNA, this is a 200% improvement. Now add your mother’s mtDNA, and so on. However, with this in mind, please note the next myth:
2. I’m going to send in my DNA sample and get back my entire family tree.
Sorry. DNA alone cannot tell a person who their great-grandmother was, or what Italian village their great-great grandfather came from. Genetic genealogy can be an informative and exciting addition to traditional research, and can sometimes be used to answer specific genealogical mysteries.
3. I would like to try genetic genealogy, but I’m terrified of needles.
Good news! Genetic genealogy firms don’t use blood samples to collect cells for DNA testing. Instead, these companies send swabs or other means to gently obtain cells from the cheek and saliva.
4. I would like to test my ancestor’s DNA, but they died years ago.
You don’t always need your ancestor’s DNA to get useful information from a genetic genealogy test. If you are male, you contain the Y-chromosome (Y-DNA) that was given to you by your father, who received it from his father, and so on. Both males and females have mitochondrial DNA (mtDNA), which was passed on to them by their mother, who received it from her mother, and so on. Everyone of us contains DNA (Y-DNA and/or mtDNA) from our ancestors that can be studied by genetic genealogy.
5. I want to test my mother’s father’s Y-DNA, but since he didn’t pass on his Y-chromosome to my mother, I’m out of luck.
Wrong! There is a very good chance that there is another source of that same Y-DNA. For instance, does your mother have a brother (your uncle) who inherited the Y-DNA from his father? Or does your mother’s father have a brother (your great-uncle) who would be willing to submit DNA for the test? Sometimes there might not be an obvious source of “lost” Y-DNA, or no one in the family is willing to take a DNA test. The secret to solving this problem is to do what every good genealogist does – use traditional genealogical research (paper records, census information, etc) to “trace the DNA”. Follow the line back while tracing descendants in order to find someone who is interested in learning more about their Y-DNA. This applies to finding a source of mtDNA as well.
6. Only men can submit DNA for genetic genealogy tests, since women do not have the Y-chromosome.
Wrong! Most genetic genealogy testing companies also offer mtDNA testing. Both men and women have mtDNA in their cells and can submit that DNA for testing. In addition, women can test their father’s, brother’s, or some other male relative’s Y-DNA to learn more about their paternal ancestral line, even though they did not inherit the Y-chromosome.
7. My genetic genealogy test will also reveal my propensity for diseases associated with the Y-chromosome and mtDNA.
Wrong, thank goodness. Most of the information obtained by genetic genealogy tests has no known medical relevancy, and these firms are not actively looking for medical information. It is important to note, however, that some medical information (such as infertility detected by DYS464 testing or other diseases detectable by a full mtDNA sequence) might inadvertently be revealed by a genetic genealogy test.
8. I don’t like the thought of a company having my DNA on file or my losing control over my DNA sample.
This is, of course, an understandable concern. However, most testing firms give a client two options: the DNA is either immediately destroyed once the tests are run, or it is securely stored for future testing. If the DNA is stored, the firm will typically destroy the DNA upon request. If the long-term storage of DNA is a concern, be sure to research the company’s policy before sending in a sample.
9. If my test reveals Native American ancestry, I plan to join a particular Native American affiliation group.
Although genetic genealogy can potentially reveal Native American ancestry (for instance, my mtDNA belongs to the Native American haplogroup A2), it is incredibly unlikely that this information will be sufficient to positively identify the specific source of the lineage (such as a tribe) or allow membership in a particular Native American affiliation.
10. My DNA is so boring that genetic genealogy would be a waste of time and money.
Very wrong! A person’s DNA is a very special possession – although everyone has DNA, everyone’s DNA is different (okay, except identical twins – if your identical twin has been tested, you should think twice about buying the same test!). As humans settled the world, Y-DNA and mtDNA spread and mixed randomly. As a result, it is impossible to guess with 100% assurance that a person’s Y-DNA or mtDNA belongs to a particular haplogroup (a related family of DNA sequences) without DNA testing.
BONUS MYTH: My genetic genealogy test says that my mtDNA belongs to Haplogroup A2. Juanita the Ice Maiden, a frozen mummy discovered in the Andes Mountains in Peru also has Haplogroup A2 mtDNA. Therefore, she must be my ancestor!

DNA Testing - Are You Raising Someone Else's Child?

Paternity Testing – Are you raising someone else’s child?
Back in the 1700s, the best way to determine paternity was by a good hard look at the child, followed by a good hard look at the father. Enough coincidences and maybe a relationship could be proposed. A hundred years later, eye colour was discovered to be a paternity identifier. This theory has had its flaws exposed because of recent DNA advances. We now know that eye colour is determined by at least six alleles, or genetic markers. Paternity testing has become a lot easier and affordable over the past few years due to advances in DNA science. Although an estimated 200,000 DNA tests are conducted each year by states needing to sort child-support and welfare issues, few people are willing to conduct their own at-home paternity test because they don’t realize the simplicity and convenience of an at-home paternity test.
How does a home DNA test work?
Paternity testing requires a painless sample from both the child and possible father. Even without a sample from the mother, DNA paternity test results are up to 99.9999% accurate–that’s one-in-a-million odds your results are incorrect. Most companies provide a free home kit for you to provide the samples and require you to send the kit back to the laboratory with the accompanying fee.
Because many companies are aware of the discomfort of drawing blood from a child in order to get a sample, buccal (mouth) swabs are being accepted as an alternative. By gently massaging the inside of the child’s mouth, cheek cells are collected. These cells are then sent to the lab for testing. Labs analyze up to sixteen genetic markers of the child and match them against the markers of the alleged father. Because each of us receives half our genetic markers from each parent, the results of DNA paternity testing are still accurate without the DNA information of the mother. Most labs will have results in 10 days and charge about $290 for a basic paternity verification test.
What else can a DNA test do?
DNA kits can also be used to analyze siblingship, establish cousin or grandparent relationships, determine twin zygosity (i.e. whether twins are fraternal or identical), identify ancestral origin, verify Native American decent, assure parents they left the hospital with the right baby, and most important, provide legal evidence – be prepared to pay a bit more for legal tests. Legal tests can be used to settle adoption issues, settle child-support disputes, and provide information for immigration files.
How to choose a DNA laboratory
Accreditation is a vital part of choosing a laboratory. Accredited labs have an annual audit and inspection, undergo internal and external reviews, and have their equipment calibrated for accuracy. Look for an ISO and/or AABB certification. Accredited labs will have a good reputation and near 100% track record for court cases.
Look for hidden fees. Some companies will charge you for the kit and then charge you again for the results. Also, double check when you order your kit that you’re only buying the results you need.
Ask about privacy. Make sure that your identity and intentions are kept secure.
Enjoy piece of mind
Be confident that the questions you have can be answered. DNA testing is safe and stress-free. Find a free kit and an information packet and you’re on your way to getting the piece of mind that you deserve.